Detailed analysis of chick optic fissure closure reveals Netrin-1 as an essential and conserved mediator of epithelial fusion during vertebrate embryogenesis.
Holly Hardy, James G. D. Prendergast, Aara Patel, Sunit Dutta, Violeta Trejo-Reveles, Hannah Kroeger, Andrea R. Yung, Lisa V. Goodrich, Brian P. Brooks, Jane C. Sowden, Joe Rainger
The paper analyzes chick optic fissure closure, identifying Netrin-1 as a conserved mediator of epithelial fusion essential for vertebrate development and linked to human coloboma.
eLife · Jun 4, 2019Peer-reviewedDevelopmental Biology