Lisa V. Goodrich

A comparative single-cell transcriptomic atlas for diverse populations of vertebrate hair cells

The paper constructs a cross-species single-cell transcriptomic atlas of hair cells across multiple vertebrates and identifies conserved and species-specific gene expression programs.

Molecularly defined auditory neuron subtypes show different vulnerabilities to noise- and age-related synaptopathy in mice

The paper identifies auditory neuron subtypes in mice and shows that Ia neurons are more resilient to noise and age-related synaptopathy than Ib/Ic neurons.

Modularity in the DCC extracellular domain elicits distinct effects on axon guidance

The paper shows that distinct modules in the DCC extracellular domain are essential for specific axon guidance functions in mice.

Combinatorial transcriptional regulation establishes subtype-appropriate synaptic properties in auditory neurons

The paper shows that combinatorial Maf transcription factors establish subtype-specific synaptic properties in spiral ganglion neurons.

An Anatomical and Physiological Basis for Flexible Coincidence Detection in the Auditory System

The paper explains how octopus cells in the auditory brainstem detect coincident inputs on both millisecond and submillisecond time scales, enhancing the ability to process complex sounds.

Lateral olivocochlear neurons modulate cochlear responses to noise exposure

This study investigates how lateral olivocochlear neurons modulate cochlear responses to noise exposure and finds that their ablation leads to worsened auditory function after recovery.

The auditory midbrain mediates tactile vibration sensing

The paper shows that the auditory midbrain encodes high-frequency mechanical vibrations detected by Pacinian corpuscles, enabling behavioral responses to tactile vibrations.

Multiple Guidance Mechanisms Control Axon Growth to Generate Precise T-shaped Bifurcation during Dorsal Funiculus Development in the Spinal Cord

The paper shows that multiple guidance factors, including Netrin-1 and Slit proteins, are required for proper axon bifurcation in the dorsal funiculus during spinal cord development.

High temporal frequency light response in mouse retina requires FAT3 signaling in bipolar cells

This study identifies FAT3's role in bipolar cells for high-frequency light response in mouse retina, showing its necessity for synaptic localization of GRIK1.

Experience-dependent flexibility in a molecularly diverse central-to-peripheral auditory feedback system

The paper characterizes olivocochlear neurons during development and after sound exposure, identifying distinct subtypes and their gene expression changes, with a focus on neuropeptide-enriched subtypes that respond to acoustic trauma.

Regulation of Auditory Sensory Neuron Diversity by Runx1

This study shows that Runx1 regulates the diversity of auditory sensory neurons in mice, influencing their subtype identities and functional properties through postnatal plasticity.

Diversity of developing peripheral glia revealed by single cell RNA sequencing

This study uses single-cell RNA sequencing to analyze developing and mature glia in peripheral sensory ganglia, revealing transcriptional differences and shared molecular features across glial subtypes.

Early neuronal processes interact with glia to establish a scaffold for orderly innervation of the cochlea

The paper investigates how spiral ganglion neurons navigate through the cochlea by interacting with glia and other cellular structures to form ordered connections with hair cells.

Detailed analysis of chick optic fissure closure reveals Netrin-1 as an essential and conserved mediator of epithelial fusion during vertebrate embryogenesis.

The paper analyzes chick optic fissure closure, identifying Netrin-1 as a conserved mediator of epithelial fusion essential for vertebrate development and linked to human coloboma.