Joe Rainger

The paper identifies cis-regulatory elements and transcription factors involved in optic fissure closure using chicken embryos, linking them to human coloboma genes.

FuChi is a new Fucci-based system in chickens that accurately tracks cell cycle phases in vivo, improving upon existing models by distinguishing all phases and enabling detailed developmental studies.

The paper generates a Netrin-1 fluorescent reporter chicken line to study molecular signatures during optic fissure closure and identifies new markers and pathways for developmental tissue fusion.

The paper examines cell adhesion marker expression dynamics during optic fissure fusion, identifying unique profiles in pioneer cells and the temporal role of SNAI2.

The paper identifies 10 genes with conserved expression in the optic fissure across vertebrates and suggests EMX2, NID1, and EPHB3 as novel candidate genes for ocular coloboma.

This study identifies a critical genomic region on the X chromosome linked to anophthalmia in mice but finds no clear causative mutation, suggesting regulatory changes may underlie the phenotype.

The paper analyzes chick optic fissure closure, identifying Netrin-1 as a conserved mediator of epithelial fusion essential for vertebrate development and linked to human coloboma.

The paper identifies a missense variant in OLFML3 as a candidate for severe goniodysgenesis and glaucoma in Border Collies.