Andrea R. Yung

Modularity in the DCC extracellular domain elicits distinct effects on axon guidance

The paper shows that distinct modules in the DCC extracellular domain are essential for specific axon guidance functions in mice.

Combinatorial transcriptional regulation establishes subtype-appropriate synaptic properties in auditory neurons

The paper shows that combinatorial Maf transcription factors establish subtype-specific synaptic properties in spiral ganglion neurons.

Multiple Guidance Mechanisms Control Axon Growth to Generate Precise T-shaped Bifurcation during Dorsal Funiculus Development in the Spinal Cord

The paper shows that multiple guidance factors, including Netrin-1 and Slit proteins, are required for proper axon bifurcation in the dorsal funiculus during spinal cord development.

Systematically characterizing the roles of E3-ligase family members in inflammatory responses with massively parallel Perturb-seq

The paper uses Perturb-seq to systematically study 1,130 E3 ligases and their roles in inflammatory responses in dendritic cells, revealing co-functional modules and genetic interactions.

The Tabula Sapiens: a multiple organ single cell transcriptomic atlas of humans

Nearly 500,000 cells from 24 human tissues, many from one donor, characterize over 400 cell types and enable within-donor study of T-cell clones, B-cell mutation rates and splicing.

Diversity of developing peripheral glia revealed by single cell RNA sequencing

This study uses single-cell RNA sequencing to analyze developing and mature glia in peripheral sensory ganglia, revealing transcriptional differences and shared molecular features across glial subtypes.

Detailed analysis of chick optic fissure closure reveals Netrin-1 as an essential and conserved mediator of epithelial fusion during vertebrate embryogenesis.

The paper analyzes chick optic fissure closure, identifying Netrin-1 as a conserved mediator of epithelial fusion essential for vertebrate development and linked to human coloboma.