Defining the importance of the arginine loop region of protegrin-1 for antimicrobial activity towards colistin-resistant Klebsiella pneumoniae.
Christina DeBarro, Sofia Assent, Hannah Makhecha, Noor Radde, Rakesh Krishnan, Justin R. Randall, César de la Fuente‐Núñez, Renee M. Fleeman
The paper investigates how mutations in protegrin-1 affect its antimicrobial activity against colistin-resistant Klebsiella pneumoniae, finding structural changes have a greater impact than charge reduction.
bioRxiv · May 28, 2025 · PreprintMicrobiology