TDP-43 dysfunction restricts dendritic complexity by inhibiting CREB activation and altering gene expression
Josiah J. Herzog, Weijin Xu, Mugdha Deshpande, Reazur Rahman, Hannah Suib, Avital Adah Rodal, Michael Rosbash, Suzanne Paradis
This study identifies CREB signaling as a pathway inhibited by TDP-43 dysfunction, leading to reduced dendritic complexity in neurodegenerative diseases.
Proceedings of the National Academy of Sciences · May 11, 2020Peer-reviewedNeuroscience