AI-guided screen identifies probucol-mediated mitophagy enhancement through modulation of lipid droplets
Natalia Moskal, Naomi P. Visanji, Olena Gorbenko, Vijay Narasimhan, Hannah Tyrrell, Jess Nash, Peter N. Lewis, G. Angus McQuibban
The paper identifies probucol as a mitophagy enhancer through AI-guided screening, showing it improves dopaminergic neuron survival in models of mitochondrial damage.
bioRxiv · May 18, 2022 · PreprintNeuroscience