Naomi P. Visanji

The paper constructs a single-nucleus transcriptome atlas of the orbitofrontal cortex in ALS and identifies cell-type-specific transcriptional changes, introducing a deep learning model to analyze alternative polyadenylation.

The paper uses TRAP-Bac to study translational gene expression changes in direct and indirect pathways of LDOPA-induced dyskinesia in mice, identifying pathway-specific gene expression patterns.

The paper investigates molecular subtypes in PSP by analyzing tau seeding activity and identifies immune-related pathways associated with disease progression.

The paper identifies probucol as a mitophagy enhancer through AI-guided screening, showing it improves dopaminergic neuron survival in models of mitochondrial damage.

This study introduces a modified Real-Time Quaking-induced Conversion assay to assess alpha-synuclein seeding activity in multiple system atrophy, revealing heterogeneity in seeding behavior across brain regions.

This study identifies genetic modifiers of LRRK2 mutations in Parkinson's disease, finding a significant variant in CORO1C and a polygenic risk score effect on penetrance.