Gene-signatures predict biologically relevant dose-response potencies in phenotypic assays
Steffen Renner, Christian Bergsdorf, Rochdi Bouhelal, Magdalena Koziczak‐Holbro, Andrea Marco Amati, Valerie Techer-Etienne, Ludivine Flotte, Nicole Reymann, Karen Kapur, Sebastian Hoersch, Edward J. Oakeley, Ansgar Schuffenhauer, Hanspeter Gubler, Eugen Lounkine, Pierre J. Farmer
The paper introduces a method to quantify gene-signature dose-response potencies as EC50 and IC50 values, validated using two signaling pathways and showing high correlation with orthogonal readouts.
bioRxiv · Oct 9, 2019 · PreprintBioinformatics