Author

Edward J. Oakeley

Novartis Institutes for BioMedical ResearchORCID 0000-0001-6226-7470Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Research Focus:perturbation response prediction· 1

Frequent Co-Authors

Adriano AguzziiD· 1 shared Andrea ArmaniiD· 1 shared Andrea Marco AmatiiD· 1 shared Anna SpinelliiD· 1 shared Ansgar SchuffenhaueriD· 1 shared Ashutosh DhingraiD· 1 shared Britta Knapp· 1 shared Chiara TrevisaniD· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperGenomics

Adriano AguzziORCID

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2 papers

Recent·Most cited

GenomicsbioRxivPreprintMay 25, 2022

Robust and Versatile Arrayed Libraries for Human Genome-Wide CRISPR Activation, Deletion and Silencing

Jiang‐An Yin, Lukas D. Frick, Manuel C. Scheidmann…·Adriano Aguzzi

The paper constructs genome-wide CRISPR libraries for gene ablation, activation, and silencing with high efficacy and reports novel gene regulators and modifiers.

19 citations

humanCRISPR screen

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BioinformaticsbioRxivPreprintOct 9, 2019

Gene-signatures predict biologically relevant dose-response potencies in phenotypic assays

Steffen Renner, Christian Bergsdorf, Rochdi Bouhelal…·Pierre J. Farmer

The paper introduces a method to quantify gene-signature dose-response potencies as EC50 and IC50 values, validated using two signaling pathways and showing high correlation with orthogonal readouts.

DOI 10.1101/799106

bulk RNA-seqstatistical model

𝕏 PostBluesky