Steffen Renner

A high-throughput compound screen identifies multiple druggable targets in Plasmodium falciparum transmission stages

This study identifies three druggable targets in Plasmodium falciparum gametocytes using high-throughput screening and reveals resistance mechanisms for one compound.

Cell type-focused compound screen in human organoids reveals CK1 and MAPK11 inhibition protects cone photoreceptors from death

The paper screens 2,707 compounds in human retinal organoids to identify those that protect or damage cone photoreceptors, finding CK1 and MAPK11 inhibitors as protective.

Screening of a chemogenetic library unveils dual-stage antimalarials with low cytotoxicity

This study screens a chemogenetic library to identify antimalarial compounds with dual-stage activity against Plasmodium liver and blood stages, showing low cytotoxicity.

DRUG-seq Provides Unbiased Biological Activity Readouts for Drug Discovery

DRUG-seq provides high-throughput, unbiased transcriptomic data for drug discovery, demonstrating reproducibility and mechanism-of-action resolution for diverse compounds.

Gene-signatures predict biologically relevant dose-response potencies in phenotypic assays

The paper introduces a method to quantify gene-signature dose-response potencies as EC50 and IC50 values, validated using two signaling pathways and showing high correlation with orthogonal readouts.