Synaptic changes contribute to persistent extra-motor behaviour deficits in the rNLS8 TDP-43 mouse model of amyotrophic lateral sclerosis
Wei Luan, Rebecca San Gil, Lidia Madrid San Martin, Maize C. Cao, Florencia Vassallu, Heledd Brown-Wright, Adekunle T. Bademosi, Yi Jia Chye, Hao Yu Wu, Mu Sheen Chang, Emma L. Scotter, Catherine A. Blizzard, Lionel Muller Igaz, Adam K. Walker
This study identifies persistent extra-motor behavioural deficits in rNLS8 TDP-43 mice, linked to synaptic gene expression and splicing changes that persist even after motor recovery.
bioRxiv · Mar 4, 2025 · PreprintNeuroscience