Adaptive mutations at lysine residues of PRRSV nsp12 enable evasion of host proteasomal and selective autophagic degradation
Yongjie Chen, Zhan He, Zishen Chen, Ling Huang, Haotong Lu, Siyong Zeng, Baoying Huang, Chunhe Guo
This study identifies adaptive mutations in PRRSV nsp12 that enable evasion of host proteasomal and autophagic degradation, enhancing viral replication and infectivity.
bioRxiv · Sep 2, 2025 · PreprintMicrobiology