Post-mortem evidence for a reciprocal relationship between genomic DNA damage and alpha-synuclein pathology in dementia with Lewy bodies.
David J. Koss, Olivia Todd, Hariharan Menon, Zoe Anderson, Tamsin Yang, Johannes Attems, Fiona E. N. LeBeau, Daniel Erskine, Tiago F. Outeiro
This study shows DNA damage and repair dysfunction are linked to alpha-synuclein pathology in dementia with Lewy bodies, with DNA damage-derived material found within Lewy bodies.
bioRxiv · Apr 24, 2024 · PreprintNeuroscience