Daniel Erskine

This study investigates neuroinflammation and metabolic dysfunction in POLG-related mitochondrial epilepsy using post-mortem brain tissues and proteomic analysis.

This study shows that glycation of alpha-synuclein increases its aggregation and neuroinflammatory responses, linking type 2 diabetes and Parkinson's disease.

This study examines alpha-synuclein pathology in metachromatic leukodystrophy (MLD) brain tissue, finding seed-competent alpha-synuclein conformers in juvenile-onset cases, similar to Lewy body diseases.

This study shows DNA damage and repair dysfunction are linked to alpha-synuclein pathology in dementia with Lewy bodies, with DNA damage-derived material found within Lewy bodies.

The paper investigates whether Lewy bodies form due to impaired autophagy and mitochondrial dysfunction, finding enriched autophagic markers and proteomic evidence of aggresome-like pathways in Lewy bodies.

This study identifies inflammation and autophagy dysfunction, linked to mTOR pathway activation, as key mechanisms in metachromatic leukodystrophy using postmortem tissue analysis.