Structural insights into Pseudomonas aeruginosa lysine-specific uptake mechanism for extremely low pH regulation
Deniz Bicer, Rei Matsuoka, Aurélien F. A. Moumbock, Preethi Sukumar, Albert Suades, Harish Cheruvara, Andrew Quigley, David Drew, Els Pardon, Jan Steyaert, Peter J. F. Henderson, Martin Caffrey, Julia J. Griese, Emmanuel Nji
The paper reports the cryo-EM structure of Pseudomonas aeruginosa LysP bound to lysine and a nanobody, revealing its transport mechanism and inhibition by L-4-thialysine.
Nature Communications · Dec 4, 2025Peer-reviewedBiochemistry