Author

Deniz Bicer

Aarhus University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Bioengineering· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:bacteria (other)· 1 Assay:bulk RNA-seq· 1 Assay:cryo-EM· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Søren ThirupiD· 3 shared Jens Preben MorthiD· 2 shared Laura RotilioiD· 2 shared Alexander Andersen· 1 shared Alexander F. SandahliD· 1 shared Anders Dupont BørglumiD· 1 shared Andreas SommerfeldtiD· 1 shared Andrew Quigley· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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3 shared papersBiochemistry

Søren ThirupORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Fragment Based Active Site Exploration of Urethane Hydrolases Reveals a Diversity of Urethane Binding Modes

Deniz Bicer, Д. И. Кочубей, Rosie Graham, Samuel Peña‐Díaz, Laura Rotilio, Nikolaj L. Villadsen, Andreas Sommerfeldt, Martin B. Johansen, Alexander F. Sandahl, Søren Thirup, Jens Preben Morth, Daniel E. Otzen

The paper uses fragment-based methods to explore urethanase active sites and identifies diverse binding modes for polyurethane fragments.

Acta Crystallographica Section D Structural Biology · Oct 23, 2026Peer-reviewedBiochemistry

EnZight: A Structure-Guided Algorithm to Identify and Prioritize Substitution Hotspots for Enzyme Engineering

Rune Rahbek Oestergaard, Mikkel Lyskjær Jensen, Suzana Siebenhaar, Deniz Bicer, Peter Wad Sackett, Alexander Andersen, Matteo Tiberti, Elena Papaleo, Serina L. Robinson, Søren Thirup, Peter Westh, Laura Rotilio, Jens Preben Morth

EnZight identifies and prioritizes substitution hotspots in enzymes using structural alignment, demonstrating effectiveness in improving catalytic activity and thermostability.

bioRxiv · Sep 10, 2026 · PreprintBioengineering

Rare missense variants of the leukocyte common antigen related receptor (LAR) display reduced activity in transcellular adhesion and synapse formation

Mathias Kaas Ollendorff, Nicolas Chofflet, Deniz Bicer, Sune Skeldal, Jinjie Duan, Benjamin Feller, Joachim Vilstrup, Rosa Groth, Suganya Sivagurunathan, Hesam Dashti, Jan Skov Pedersen, Thomas Mears Werge, Anders Dupont Børglum, Beth A. Cimini, Thouis R. Jones, , Simon Glerup

The paper identifies rare missense variants in LAR that destabilize the extracellular domain, disrupt LAR:NGL-3 interactions, and impair synaptic adhesion and synaptogenesis.

bioRxiv · Feb 16, 2025 · PreprintNeuroscience

Structural insights into Pseudomonas aeruginosa lysine-specific uptake mechanism for extremely low pH regulation

Deniz Bicer, Rei Matsuoka, Aurélien F. A. Moumbock, Preethi Sukumar, Harish Cheruvara, Andrew Quigley, Els Pardon, Jan Steyaert, Peter J.F. Henderson, Martin Caffrey, Julia J. Griese, Emmanuel Nji

The paper reports the cryo-EM structure of Pseudomonas aeruginosa LysP bound to lysine and a nanobody, revealing its transport mechanism and inhibition by L-4-thialysine.

bioRxiv · May 17, 2024 · PreprintBiochemistry