α-Synuclein aggregation intermediates form fibril polymorphs with distinct prion-like properties
Surabhi Mehra, Sahil Ahlawat, Harish Kumar, Debalina Datta, Ambuja Navalkar, Nitu Singh, Komal Patel, Laxmikant G. Gadhe, Pradeep Kadu, Rakesh Kumar, Narendra Nath Jha, Arunima Sakunthala, Ajay Singh Sawner, Ranjith Padinhateeri, Jayant B. Udgaonkar, , Samir Kumar Maji
This study identifies two distinct α-synuclein fibril polymorphs with different structural and functional properties linked to prion-like behavior in Parkinson's disease.
Journal of Molecular Biology · Jul 27, 2022Peer-reviewedNeuroscience