Ranjith Padinhateeri

This study introduces a model showing that active nucleosome remodeling influences chromatin condensate structure and dynamics by driving swelling, mixing, and segregation.

This study develops coarse-grained models to show how nucleosome spacing and ATP-dependent remodeling influence chromatin condensate structure, dynamics, and organization.

The paper develops a data-driven non-equilibrium model of chromatin polymer behavior, showing that active forces at specific scales explain anomalous fluctuations and 3D organization.

The paper uses Monte Carlo simulations to study how chromatin compaction and DNA breaks influence gene translocation probabilities.

The paper investigates how centromere clustering states in Cryptococcus neoformans influence 3D genome architecture during the cell cycle, revealing unique organizational principles.

The paper shows that loop extrusion dominates dynamic properties of chromatin, even when intra-chromatin interactions dominate static structure.

The paper investigates how pulling forces and intra-chromatin interactions influence chromosome pairing and unfolding during meiosis in fission yeast.

The paper studies histone modification spreading using a reaction-diffusion model, showing diffusion and enzyme degradation limit domain size and produce modification profiles comparable to S. pombe H3K9me3 data.

The paper investigates how chromatin compaction affects protein search kinetics using models and experimental data, finding optimal compaction minimizes protein residence time.

The paper uses shear flow to differentiate between two types of molecular machine activities in chromatin loops through simulation analysis.

This study identifies two distinct α-synuclein fibril polymorphs with different structural and functional properties linked to prion-like behavior in Parkinson's disease.

This study investigates how the size of α-synuclein fibril seeds affects their amplification, cellular uptake, and toxicity, revealing distinct mechanisms for small and large seeds.

The paper identifies kinetic parameters and connectivity changes in insulin signaling that are disrupted in hyperinsulinemia.

The paper identifies kinetic parameters and connectivity changes in insulin signaling that are disrupted in hyper-insulinemic states.

This study shows that α-synuclein undergoes liquid-liquid phase separation, which transitions to solid amyloid fibrils, contributing to Parkinson's disease pathogenesis.

This study shows Orc4 stabilizes centromeric chromatin by interacting with CENPA and Mcm2, and its spatiotemporal localization is crucial for kinetochore stability in C. albicans.