Laxmikant G. Gadhe

An N-terminal ATTR Fibril Segment Promotes Transthyretin Amyloid Nucleation and Polymorphism

This study identifies an N-terminal ATTR fibril segment that promotes TTR amyloid nucleation and polymorphism through structural compatibility and templating activity.

TAF15 amyloids propagate via defined motifs in a prion-like fashion

This study shows TAF15 forms amyloid fibrils and propagates prion-like between cells, identifying specific motifs that drive its aggregation in vitro and in cells.

Reverse-engineering amyloid strains with generative protein design

This study uses generative protein design to explore how sequences encode amyloid fibril structures, showing a continuous compatibility between sequences and a common amyloid fold.

Amyloid Explorer: a global atlas of amyloid fibril structures and thermodynamic principles

Amyloid Explorer provides a standardized, thermodynamically annotated atlas of amyloid fibril structures, revealing conserved assembly rules and enabling mechanistic insights.

α-Synuclein aggregation intermediates form fibril polymorphs with distinct prion-like properties

This study identifies two distinct α-synuclein fibril polymorphs with different structural and functional properties linked to prion-like behavior in Parkinson's disease.

Size-dependent secondary nucleation and amplification of α-synuclein amyloid fibrils

This study investigates how the size of α-synuclein fibril seeds affects their amplification, cellular uptake, and toxicity, revealing distinct mechanisms for small and large seeds.

Liquid-liquid phase separation and liquid-to-solid transition mediate α-synuclein amyloid fibril containing hydrogel formation

This study shows that α-synuclein undergoes liquid-liquid phase separation, which transitions to solid amyloid fibrils, contributing to Parkinson's disease pathogenesis.