Samir Kumar Maji

Development of an RNA Aptamer as a Therapeutic Agent for Synucleinopathies

This paper develops an RNA aptamer, 1R6, that targets synuclein and shows therapeutic potential in synucleinopathies by inhibiting aggregation and promoting disaggregation.

Phase separation as a concentrating mechanism of protein/peptide hormones for the secretory granule storage

This study shows that protein/peptide hormones undergo phase separation at the TGN, forming amyloid-like structures that enable efficient storage and regulated release in secretory granules.

α-Synuclein aggregation intermediates form fibril polymorphs with distinct prion-like properties

This study identifies two distinct α-synuclein fibril polymorphs with different structural and functional properties linked to prion-like behavior in Parkinson's disease.

Size-dependent secondary nucleation and amplification of α-synuclein amyloid fibrils

This study investigates how the size of α-synuclein fibril seeds affects their amplification, cellular uptake, and toxicity, revealing distinct mechanisms for small and large seeds.

Liquid-liquid phase separation and liquid-to-solid transition mediate α-synuclein amyloid fibril containing hydrogel formation

This study shows that α-synuclein undergoes liquid-liquid phase separation, which transitions to solid amyloid fibrils, contributing to Parkinson's disease pathogenesis.

Unraveling the aggregation dynamics of amyloidogenesis: A data-driven mathematical modeling approach

This paper develops a data-driven mathematical model to understand amyloidogenesis dynamics and predict therapeutic strategies for neurodegenerative diseases.