Dynamic chromatin targeting of BRD4 stimulates cardiac fibroblast activation
Matthew S. Stratton, Rushita Adhikari Bagchi, Marina Barreto Felisbino, Rachel A. Hirsch, Harrison E. Smith, Andrew S. Riching, Blake T. Enyart, Keith A. Koch, Maria A. Cavasin, Michael Alexanian, Kunhua Song, Jun Qi, Madeleine E. Lemieux, Deepak Srivastava, Maggie P. Y. Lam, , Timothy A. McKinsey
This study shows BRD4 promotes cardiac fibrosis by dynamically targeting chromatin and activating gene expression in fibroblasts, revealing a signaling pathway involved in heart failure.
Circulation Research · Aug 14, 2019Peer-reviewedMolecular Biology