HDAC11 inhibition triggers bimodal thermogenic pathways to circumvent adipocyte catecholamine resistance
Emma Louise Robinson, Rushita Adhikari Bagchi, Jennifer L. Major, Bryan C. Bergman, Jennifer L. Matsuda, Timothy A. McKinsey
This study shows that inhibiting HDAC11 in adipocytes increases UCP1 expression and thermogenesis, even when beta-AR signaling is blocked.
Journal of Clinical Investigation · Aug 23, 2023Peer-reviewedMolecular Biology