Endothelial Piezo1 regulates muscle AKT abundance and mechanically induced muscle hypertrophy
Fiona Bartoli, Peter George Tickle, Harrison Gallagher, Marjolaine Debant, Chew Weng Cheng, Timothy Simon Futers, Hélène N. Daou, Nadira Y. Yuldasheva, David J. Beech, Thomas Scott Bowen
This study shows endothelial Piezo1 promotes mechanical overload-induced muscle hypertrophy by regulating AKT abundance, but not muscle regeneration.
bioRxiv · Sep 2, 2025 · PreprintPhysiology