Multi-omic analysis of the ciliogenic transcription factor RFX3 reveals a role in promoting activity-dependent responses via enhancing CREB binding in human neurons
Jenny F. Lai, Didem Demirbas, Kaitlyn Phillips, Boxun Zhao, Harrison Wallace, Megan Seferian, Tojo Nakayama, Holly K. Harris, Aikaterini Chatzipli, Eunjung Alice Lee, Timothy W. Yu
This study investigates RFX3's role in human neurons, showing that monoallelic loss disrupts synaptic gene expression and activity-dependent responses by impairing CREB binding.
bioRxiv · Feb 27, 2025 · PreprintNeuroscience