Author

Didem Demirbas

Broad InstituteORCID 0000-0003-2865-2708Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Timothy W. YuiD· 3 shared Eunjung Alice LeeiD· 2 shared Jenny F. LaiiD· 2 shared Aikaterini ChatzipliiD· 1 shared Ailsa M. JeffriesiD· 1 shared Alexander RotenbergiD· 1 shared Allie K. TollesiD· 1 shared Amanda LiebhardtiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersNeuroscience

Timothy W. YuORCID

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3 papers

Recent·Most cited

NeurosciencebioRxivPreprintMar 26, 2026

Postnatal gene restoration in succinic semialdehyde dehydrogenase deficiency (SSADHD) reveals phenotype reversibility

H. Lee, Gabrielle E. McGinty, Amanda Liebhardt…·Alexander Rotenberg

This study shows that restoring the ALDH5A1 gene in a mouse model of SSADHD reverses hyperactivity and reduces GHB levels, improving survival.

DOI 10.64898/2026.03.24.713250

mouseexperimental assay

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NeurosciencebioRxivPreprintFeb 27, 2025

Multi-omic analysis of the ciliogenic transcription factor RFX3 reveals a role in promoting activity-dependent responses via enhancing CREB binding in human neurons

Jenny F. Lai, Didem Demirbas, Kaitlyn Phillips…·Timothy W. Yu

This study investigates RFX3's role in human neurons, showing that monoallelic loss disrupts synaptic gene expression and activity-dependent responses by impairing CREB binding.

6 citations

humanbulk RNA-seq

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NeuroscienceCell ReportsPeer-reviewedDec 28, 2023

ATM-deficiency induced microglial activation promotes neurodegeneration in Ataxia-Telangiectasia

Jenny F. Lai, Didem Demirbas, Junho Kim…·Eunjung Alice Lee

This study shows that ATM deficiency causes microglial activation, which contributes to neurodegeneration in Ataxia-Telangiectasia by inducing cytotoxicity in neurons.

44 citationstop 5%

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