Brunner syndrome associated MAOA dysfunction in human dopaminergic neurons results in NMDAR hyperfunction and increased network activity.
Yan Shi, Jon-Ruben van Rhijn, Maren Bormann, Britt Mossink, Monica Frega, Hatice Recaioglu, Marina Hakobjan, Teun M. Klein Gunnewiek, Chantal Schoenmaker, Elizabeth E. Palmer, Laurence Olivier Faivre, Sarah Kittel‐Schneider, Dirk Schubert, Han G. Brunner, Barbara Franke, Nael Nadif Kasri
This study shows that MAOA dysfunction in Brunner syndrome leads to increased NMDAR activity and neuronal network hyperactivity in dopaminergic neurons.
bioRxiv · Oct 28, 2020 · PreprintNeuroscience