Author

Marina Hakobjan

Radboud University Medical Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Assay:scRNA-seq· 1 Approach:statistical model· 1 Research Focus:variant calling· 1 Assay:whole-exome sequencing· 1

Frequent Co-Authors

Barbara FrankeiD· 3 shared Britt MossinkiD· 2 shared Dirk SchubertiD· 2 shared Han G. BrunneriD· 2 shared Jon-Ruben van RhijniD· 2 shared Maren BormanniD· 2 shared Monica FregaiD· 2 shared Nael Nadif KasriiD· 2 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersNeuroscience

Barbara FrankeORCID

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3 papers

Recent·Most cited

Whole exome sequencing in multi-incident families identifies novel candidate genes for multiple sclerosis

Julia Horjus, Tineke van Mourik-Banda, Marco A. P. Heerings, Marina Hakobjan, Ward De Witte, Dorothea J. Heersema, Anne J. Jansen, Eva M. M. Strijbis, Brigit A. de Jong, A.E.J. Slettenaar, Esther Zeinstra, Erwin L.J. Hoogervorst, Barbara Franke, W. Kruijer, Peter Joseph Jongen, , Geert Poelmans

The paper uses whole exome sequencing in multi-incident families to identify rare genetic variants associated with multiple sclerosis, finding 12 candidate genes involved in myelination and auto-immunity.

International Journal of Molecular Sciences · Sep 28, 2022Peer-reviewedGenetic & Genomic Medicine

Brunner syndrome associated MAOA dysfunction in human dopaminergic neurons results in NMDAR hyperfunction and increased network activity.

Yan Shi, Jon-Ruben van Rhijn, Maren Bormann, Britt Mossink, Monica Frega, Hatice Recaioglu, Marina Hakobjan, Teun M. Klein Gunnewiek, Chantal Schoenmaker, Elizabeth E. Palmer, Laurence Olivier Faivre, Sarah Kittel‐Schneider, Dirk Schubert, Han G. Brunner, Barbara Franke, Nael Nadif Kasri

This study shows that MAOA dysfunction in Brunner syndrome leads to increased NMDAR activity and neuronal network hyperactivity in dopaminergic neurons.

bioRxiv · Oct 28, 2020 · PreprintNeuroscience

Brunner syndrome associated MAOA dysfunction in human iPSC derived dopaminergic neurons results in dysregulated NMDAR expression and increased network activity

Yufang Shi, J.R. van Rhijn, Maren Bormann, Britt Mossink, Monica Frega, Marina Hakobjan, Sarah Kittel‐Schneider, Dirk Schubert, Han G. Brunner, Barbara Franke, Nael Nadif Kasri

This study investigates MAOA dysfunction in Brunner Syndrome using iPSC-derived dopaminergic neurons, finding increased NMDA receptor expression and network activity.

bioRxiv · Aug 21, 2019 · PreprintNeuroscience