Barbara Franke

The multivariate genetic architecture of psychiatric and insulin resistance multimorbidity

This paper investigates the shared genetic architecture of psychiatric and insulin resistance conditions using multivariate GWAS and identifies potential biological mechanisms and drug candidates.

Thalamic Nuclei Volumes Across Psychiatric and Neurological Disorders: A Multi-Site Magnetic Resonance Imaging Study

This study compares thalamic nucleus volumes across multiple psychiatric and neurological disorders using MRI, finding significant volume reductions in specific regions associated with different conditions.

A normative reference for large-scale human brain dynamics across the lifespan

The paper establishes a normative reference for large-scale human brain dynamics using resting-state fMRI data from over 10,000 individuals, revealing systematic reorganization across development and ageing and disorder-specific deviations in mental health conditions.

Brain Age in Conduct Disorder: A Mega-Analysis of the ENIGMA Antisocial Behavior Working Group

This study investigates brain age differences in youth with conduct disorder compared to controls, finding accelerated brain maturation in those with adolescence-onset CD.

KCNQ1 regulates human neuronal development through mitochondrial and insulin signalling pathways

This study shows KCNQ1 regulates human neuronal development by affecting cell adhesion, mitochondrial function, and insulin signalling pathways.

Cell type-specific methylome-wide association studies of childhood ADHD symptoms

This study identifies cell type-specific DNA methylation associations with childhood ADHD symptoms using deconvolution and sequencing-based methylation data from peripheral and cord blood.

A cross-disorder analysis of CNVs finds novel loci and dose-dependent relationships of genes to psychiatric traits

The paper identifies novel CNV loci and dose-dependent gene effects across six psychiatric disorders using genome-wide analysis.

Psychiatric disorders converge on common pathways but diverge in cellular context, spatial distribution, and directionality of genetic effects

The paper identifies shared and divergent genetic mechanisms across psychiatric disorders using gene-set burden analysis of copy number variants.

Genetic liability to major psychiatric disorders contributes to multi-faceted quality of life outcomes in children and adults

This study links genetic liability to psychiatric disorders with quality of life outcomes in children and adults, finding ADHD and MDD PGSs significantly associated with lower quality of life factors.

Multiscale heterogeneity of white matter morphometry in psychiatric disorders

The paper examines white matter volume deviations in psychiatric disorders using normative modeling, finding heterogeneous patterns with some aggregation in autism and schizophrenia.

The Landscape of Shared and Divergent Genetic Influences across 14 Psychiatric Disorders

The paper identifies five genomic factors explaining most genetic variance across 14 psychiatric disorders and finds shared and disorder-specific genetic signals with distinct biological functions.

Genomic analysis of intracranial and subcortical brain volumes yields polygenic scores accounting for variation across ancestries

The paper conducts GWAS on brain volumes, identifies genetic loci, and develops polygenic scores with cross-ancestry predictive ability and causal links to neuropsychiatric disorders.

Brain-Age Prediction: Systematic Evaluation of Site Effects, and Sample Age Range and Size

The paper evaluates factors affecting brain-age prediction models using structural neuroimaging data from 35,683 individuals, finding optimal model performance with no site harmonization, age-binning, and a sample size of over 1,600.

Genetic variants for head size share genes and pathways with cancer

This study identifies 67 genetic loci associated with head size, finding strong overlaps with cancer pathways and genes, suggesting shared genetic mechanisms between head growth and cancer risk.

A human in vitro neuronal model for studying homeostatic plasticity at the network level

This study uses human iPSC-derived neuronal networks to show that homeostatic plasticity involves network re-arrangement, increased excitability, and changes in gene expression related to extracellular matrix and cell communication.

Multi-polygenic scores in psychiatry: from disorder-specific to transdiagnostic perspectives

This study examines genetic liability for psychiatric disorders using disorder-specific and transdiagnostic frameworks, finding that depression PRS is associated with multiple disorders and uncovering four functional domains aligning with RDoC.

A comparison of bioinformatics pipelines for compositional analysis of the human gut microbiome

This paper compares five bioinformatics pipelines for analyzing 16S rRNA gene sequencing data from the gut microbiome, showing how pipeline choice affects downstream statistical results and case-control conclusions.

Normative Modeling of Brain Morphometry Across the Lifespan using CentileBrain: Algorithm Benchmarking and Model Optimization

The paper benchmarks and optimizes a normative modeling framework for brain morphometry across the lifespan using MFPR, showing excellent accuracy and stability.

Whole exome sequencing in multi-incident families identifies novel candidate genes for multiple sclerosis

The paper uses whole exome sequencing in multi-incident families to identify rare genetic variants associated with multiple sclerosis, finding 12 candidate genes involved in myelination and auto-immunity.

Multilevel neural gradients reflect transdiagnostic effects of major psychiatric conditions on cortical morphology

The paper identifies a shared cortical morphology dimension across six psychiatric conditions using MRI data from 28,546 participants.

Dissociable Cellular and Genetic Mechanisms of Cortical Thinning at Different Life Stages

The paper examines age-related variations in cortical thickness across different life stages using gene expression data from a large neuroimaging dataset.

Insulinopathies of the brain? Genetic overlap between somatic insulin-related and neuropsychiatric disorders

The paper investigates genetic overlaps between neuropsychiatric disorders and insulin-related diseases, finding significant genetic correlations and suggesting potential clusters of disorders with divergent pleiotropic effects.

Subtly altered topological asymmetry of brain structural covariance networks in autism spectrum disorder across 43 datasets from the ENIGMA consortium

The paper examines hemispheric asymmetry in structural covariance networks in ASD across 43 datasets, finding altered topological features in specific brain regions.

Shared genetic influences on resting-state functional networks of the brain

This study uses a multivariate method to identify shared genetic factors influencing resting-state brain networks and finds nine replicated SNPs associated with their joint architecture.

Molecular and connectomic vulnerability shape cross-disorder cortical abnormalities

The paper investigates how molecular and connectomic vulnerabilities contribute to cortical abnormalities across multiple brain disorders using MRI data from 47,000 individuals.

Genetic background of grey matter brain networks related to attention-deficit/hyperactivity disorder

The paper identifies ten genes associated with ADHD-related grey matter brain networks in a sample of 899 individuals.

Longitudinal changes of ADHD symptoms in association with white matter microstructure: a tract-specific fixel-based analysis

The paper examines longitudinal ADHD symptom changes linked to white matter microstructure using fixel-based analysis, finding associations between symptom improvement and specific tract metrics.

Missing genetic links between general factors of brain resting-state functional magnetic resonance imaging, cognition and psychopathology

The paper investigates genetic overlap between psychopathology, cognition, and brain function using genetic correlation analyses of summary statistics from genome-wide association studies.

Dissecting the heterogeneous subcortical brain volume of Autism spectrum disorder (ASD) using community detection

This study uses community detection to identify subgroups in ASD based on subcortical brain volumes, revealing more homogeneous groups with enhanced case/control differences.

Uncovering the Genetic Architecture of Broad Antisocial Behavior through a Genome-Wide Association Study Meta-analysis.

This study identifies genetic variants associated with antisocial behavior through a genome-wide association meta-analysis, finding significant links to FOXP2 and correlations with multiple health and behavioral traits.