Sloppiness and Action Constraint in Cell State Transitions: Are Single Cells Sloppy?
Yuxuan Wang, Junda Ying, He Xiao, M W Huang, Lei Zhang, Weikang Wang
The paper analyzes single-cell dynamics during state transitions, finding that cell states are sensitive to few 'stiff' parameters and robust to many 'sloppy' parameters, suggesting a principle of least action.
bioRxiv · Feb 22, 2026 · PreprintBiophysics