Mesodermal-niche interactions direct specification and differentiation of pancreatic endocrine cells in human multilineage organoids
Georgina Goss, Alejo Torres-Cano, Raquel A. Martínez García de la Torre, Siwanarta Ma, Leila Hermosilla Andrivet, Michelle Simon, Martina Pedna, Heather Wilson, Flavia Flaviani, Alessandra Vigilante, Francesca M. Spagnoli
The paper demonstrates that mesoderm-derived cells in organoids promote endocrine commitment and β-cell differentiation in human pancreatic development.
bioRxiv · Oct 12, 2026 · PreprintDevelopmental Biology