Alessandra Vigilante

Mesodermal-niche interactions direct specification and differentiation of pancreatic endocrine cells in human multilineage organoids

The paper demonstrates that mesoderm-derived cells in organoids promote endocrine commitment and β-cell differentiation in human pancreatic development.

Spatially organized cellular communities shape functional tissue architecture in the pancreas

This study maps pancreatic cell populations across space and time in mice, revealing spatially organized niches and their functional roles in development and adult homeostasis.

The maternal inflammatory proteome during pregnancy and its role in predicting the risk of spontaneous preterm birth

The paper identifies 16 inflammatory proteins in maternal blood plasma associated with spontaneous preterm birth and shows that combining proteomic and cfRNA data improves prediction accuracy.

A single cell ATAC-seq atlas uncovers dynamic changes in chromatin accessibility during cell fate specification at the neural plate border

The paper uses scATAC-seq to study chromatin accessibility changes during neural plate border cell fate specification, identifying new regulatory mechanisms involving Foxk2.

Rejuvenating aged osteoprogenitors for bone repair

This study identifies age-related impairments in bone healing and presents a rejuvenation strategy combining Wnt-mediated osteoprogenitor expansion and intermittent fasting to restore youthful bone repair in aged mice.

Rapid and memory-efficient analysis and quality control of large spatial transcriptomics datasets

Pseudovisium enables rapid, memory-efficient analysis of high-resolution spatial transcriptomics data while preserving biological signatures and enabling cross-platform comparisons.

Endocardium-to-coronary artery differentiation during heart development and regeneration involves sequential roles of Bmp2 and Cxcl12/Cxcr4.

Quantitative lineage analysis identifies a long-term progenitor niche for the hepato-pancreato-biliary organ system

The paper identifies a long-term multipotent progenitor niche in the hepato-pancreato-biliary system using computational modeling and lineage tracing.

Identifying extrinsic versus intrinsic drivers of variation in cell behaviour in human iPS cell lines from healthy donors

The paper integrates genetic and cell biological data from human iPSC lines to identify intrinsic and extrinsic factors driving inter-individual variability in cell behavior.