Francesca M. Spagnoli

The paper demonstrates that mesoderm-derived cells in organoids promote endocrine commitment and β-cell differentiation in human pancreatic development.

This study identifies ΔNP63 as a marker for exocrine-committed multipotent progenitors in the murine pancreas, showing its role in exocrine development and differentiation.

This study maps pancreatic cell populations across space and time in mice, revealing spatially organized niches and their functional roles in development and adult homeostasis.

This paper develops a protocol to generate human iPSC-derived pancreatic organoids with proper architecture and patterning, aiming to replace animal models in studying pancreas development and disease.

The paper studies a heterozygous missense variant in GLI2 in human iPSCs and finds it impairs endocrine pancreas development and predisposes to diabetes.

The paper identifies acinar-ductal cell rearrangements driven by the IGF/PI3K pathway as a mechanism for pancreas branching morphogenesis while preserving acinar-ductal unit integrity.

The paper identifies tissue-enriched ligands involved in epithelial-endothelial crosstalk during pancreas development using scRNA-seq and computational interactomics.

The paper develops a 3D atlas of the embryonic pancreas to analyze cell interactions and spatial organization in mouse embryos.

The paper identifies a long-term multipotent progenitor niche in the hepato-pancreato-biliary system using computational modeling and lineage tracing.