Metabolic Reprogramming Coordinates Mannose and Glutamine Metabolism to Maintain Glucose Homeostasis During Glycosuria
Nadia Rashid, Moses Temitayo Otunla, Nazmul Hasan, Michael J. Hodges, Heba Qaissi, Tumininu S. Faniyan, Pontiana Ritika Clement, Penghui Lin, Mohamed M. Y. Kaddah, Teresa Cassel, Donald A. Morgan, Kamal Rahmouni, Kavaljit H. Chhabra
The paper identifies coordinated metabolic adaptations in mannose and glutamine pathways during glycosuria to maintain glucose homeostasis, showing their dependence on SGLT2 inhibitor treatment.
bioRxiv · May 22, 2026 · PreprintPhysiology