Loss of Muscleblind Splicing Factor Shortens C. elegans Lifespan by Reducing the Activity of p38 MAPK/PMK-1 and Transcription Factors ATF-7 and Nrf/SKN-1
Olli Matilainen, Ana Rita Salgado Ribeiro, Jens Verbeeren, Murat Çetinbaş, Heini Sood, Ruslan I. Sadreyev, Susana M. D. A. Garcia
This study shows that loss of MBL-1 in C. elegans reduces p38 MAPK/PMK-1 and transcription factor activity, shortening lifespan, and suggests mitochondrial stress may alleviate DM1 symptoms.
Genetics · Jul 22, 2021Peer-reviewedGenetics