Ruslan I. Sadreyev

The paper identifies a DNA-histone methylation axis that drives KMT2A amplifications and rearrangements in leukemia, revealing therapeutic targets.

The paper shows that inhibiting miR-128-3p improves muscle function and reduces aging-related pathology in multiple models.

This study identifies a YAP1-driven invasive cervical cancer subtype that evades HPV-based screening and shows it is associated with EMT and immunosuppressive myeloid cells.

This study shows metformin inhibits chromatin fragment egress from the nucleus, reducing cGAS-STING activation and chronic inflammation in aging.

The paper shows that IRES/Cap translation increases during hematopoietic and epithelial differentiation under normal conditions, correlating with lower stemness.

This paper shows YAP1 promotes therapy resistance in melanoma by altering chromatin structure and immune evasion programs, and suggests TEAD inhibitors could overcome resistance and boost immune response.

The paper identifies ELMSAN1 as a repressor of nuclear acetyl-CoA production and shows that inhibiting this interaction reprograms cancer cells to a postmitotic state, improving survival in multiple cancer models.

This study reveals bidirectional fate transitions between myeloid-biased and lineage-balanced hematopoietic stem cells using clonal phylogenetic tracing.

This study shows that microglia depletion reduces Müller cell maturation and inner retinal vascular density in mice.

The paper investigates the N-glycome changes during neuronal differentiation and finds that brain-specific N-glycans like Man-5 are programmed independently of the transcriptome.

This study identifies Pla2g2f as a neuroprotective factor that maintains lipid homeostasis and mitigates aging-associated cognitive decline in a mouse model of Alzheimer's disease.

The paper shows that reduced synMuv B gene activity in C. elegans enhances RNA interference against viral infection.

The paper uses multiomic analysis of leukemic clones in a mouse model to identify growth regulators and validate their roles in AML.

The paper shows that prenatal exposure to air pollution and maternal stress in mice causes social deficits in male offspring, which can be prevented by microbiome modulation or dopamine activation.

This study shows that cesarean delivery in prairie voles leads to long-term social and physiological changes, including impaired partner preference formation, which can be reversed with oxytocin treatment.

This study shows that the schizophrenia-associated SLC39A8 variant A391T alters N-glycosylation in the mouse brain, affecting glycoproteins involved in schizophrenia-related pathways.

This study shows that microglial complement signaling regulates astrocyte pruning and vascular development in the retina.

The paper analyzes glycosylation patterns in mouse brain regions and sexes, finding reduced complexity and minimal sex differences compared to plasma.

This study identifies Klf9 as a transcriptional regulator that suppresses symmetric self-renewal of radial-glial neural stem cells in the adult hippocampus.

The paper suggests that viruses, including SARS-CoV-2, may use NGLY1/PNG-1 to edit N-glycosylated asparagines to aspartic acid, and proposes vaccinating with N to D edited viral peptides to enhance immunity.

This study shows that loss of MBL-1 in C. elegans reduces p38 MAPK/PMK-1 and transcription factor activity, shortening lifespan, and suggests mitochondrial stress may alleviate DM1 symptoms.

This study shows that CAF-1 maintains myeloid lineage identity by regulating chromatin accessibility and transcription factor control during differentiation.