Intra-articular AAV-PHP.S mediated chemogenetic targeting of knee-innervating dorsal root ganglion neurons alleviates inflammatory pain in mice.
Sampurna Chakrabarti, Luke A. Pattison, Balint Doleschall, Rebecca H. Rickman, Helen Blake, Gerard Callejo, Paul A. Heppenstall, Ewan St. John Smith
This study uses AAV-PHP.S to deliver chemogenetic receptors to knee-innervating DRG neurons, showing that inhibitory DREADDs reduce inflammation-induced pain in mice.
Arthritis & Rheumatology · May 17, 2020Peer-reviewedNeuroscience