Sampurna Chakrabarti

This study examines mechanosensitive currents in sensory neurons lacking PIEZO2, finding no significant reduction in current sensitivity but a moderate decrease in rapidly adapting currents.

This study uses ultrasensitive proteomics to uncover nociceptor diversity and identify novel pain targets by analyzing protein expression in sensory neurons.

This study identifies TENM4 as an essential extracellular linker protein for mechanotransduction in mechanoreceptors, showing its role in touch sensitivity.

This study correlates mouse digging behavior with human pain experience, showing that digging deficits reflect pain levels and that meloxicam is more effective than gabapentin in alleviating these deficits.

This study identifies Elkin1 as a novel mechanically-activated ion channel essential for touch and pain sensation, independent of Piezo2.

The paper shows that mutations at R2756 in PIEZO2 channels reduce voltage-block, increasing mechanosensitivity in nociceptors and causing hypersensitivity to mechanical pain.

This study shows that ovine dorsal root ganglion neurons from osteochondral defect models exhibit increased excitability and TRPV1 function, indicating peripheral sensitization.

This study uses AAV-PHP.S to deliver chemogenetic receptors to knee-innervating DRG neurons, showing that inhibitory DREADDs reduce inflammation-induced pain in mice.

This study shows that TNF-α activated fibroblast-like synoviocytes sensitize knee neurons in vitro, contributing to inflammatory pain in arthritis.

This study compares the blocking effects of Ginkgolide B and picrotoxin on α3 glycine receptors, revealing unique voltage-dependent and non-competitive properties of Ginkgolide B.

This study shows that acute knee inflammation in mice sensitizes sensory neurons and reduces digging behavior, mediated by TRPV1 receptor upregulation.