Gerard Callejo

KCNK18 c.1107del frameshift in peripheral neuropathy links TRESK dysfunction to neuropathic pain

The paper identifies a frameshift mutation in KCNK18 causing TRESK dysfunction, linking it to neuropathic pain through haploinsufficiency and altered channel function.

Digging deeper into pain - an ethological behavior assay correlating well-being in mice with human pain experience.

This study correlates mouse digging behavior with human pain experience, showing that digging deficits reflect pain levels and that meloxicam is more effective than gabapentin in alleviating these deficits.

TRESK background potassium channel in MrgprA3+ pruriceptors regulates acute and chronic itch.

This study shows TRESK channels regulate non-histaminergic itch by modulating sensory neuron excitability, and enhancing TRESK function reduces acute and chronic itch in mice.

Intra-articular AAV-PHP.S mediated chemogenetic targeting of knee-innervating dorsal root ganglion neurons alleviates inflammatory pain in mice.

This study uses AAV-PHP.S to deliver chemogenetic receptors to knee-innervating DRG neurons, showing that inhibitory DREADDs reduce inflammation-induced pain in mice.

Sensitization of knee-innervating sensory neurons by tumor necrosis factor-α activated fibroblast-like synoviocytes: an in vitro, co-culture model of inflammatory pain

This study shows that TNF-α activated fibroblast-like synoviocytes sensitize knee neurons in vitro, contributing to inflammatory pain in arthritis.

Human labor pain is influenced by the voltage-gated potassium channel KV6.4 subunit

The paper identifies a genetic variant in KCNG4 associated with increased labor pain by altering KV6.4 function in uterine nociceptors.

TRESK background K+ channel deletion selectively uncovers enhanced mechanical and cold sensitivity

This study shows that deleting the TRESK K+ channel enhances mechanical and cold sensitivity in mice, indicating its role in regulating neuronal excitability for specific sensory functions.

Acid and inflammatory sensitisation of naked mole-rat colonic afferent nerves

This study investigates acid and inflammatory sensitivity of colonic afferent nerves in naked mole-rats compared to mice, showing differential responses to acid and bradykinin.

Acute inflammation sensitizes knee-innervating sensory neurons and decreases mouse digging behavior in a TRPV1-dependent manner

This study shows that acute knee inflammation in mice sensitizes sensory neurons and reduces digging behavior, mediated by TRPV1 receptor upregulation.

Naked mole-rat acid-sensing ion channel 3 forms non-functional homomers, but functional heteromers

This study shows that naked mole-rat ASIC3 forms non-functional homomers but functional heteromers with other ASIC subunits, explaining its insensitivity to acid.