Modulation of Neuronal Excitability and Plasticity by BHLHE41 Conveys Lithium Non-Responsiveness
Marius Stephan, Sergi Papiol, Mingyue Zhang, Jie Song, Samuel Matthew Frommeyer, Helen Haupt, Niels Jensen, Nirmal Raman Kannaiyan, Rajinder Gupta, Philipp Schuler, Pia Picklmann, Ruofan Li, Michael J. McCarthy, Eva Christina Schulte, Mikael Landén, , Moritz J. Rossner
This study identifies BHLHE41 as a key regulator of lithium response in bipolar disorder by showing its role in neuronal excitability and synaptic plasticity through genetic and cellular analyses.
Molecular Psychiatry · Aug 18, 2026Peer-reviewedNeuroscience