Moritz J. Rossner

This study identifies BHLHE41 as a key regulator of lithium response in bipolar disorder by showing its role in neuronal excitability and synaptic plasticity through genetic and cellular analyses.

The paper identifies amacrine cells as enriched in schizophrenia genetic risk and links this to synaptic biology, while finding retinal immune cells associated with multiple sclerosis.

This study identifies alternative polyadenylation (APA) as a molecular mechanism linking polygenic risk for schizophrenia to synaptic impairments through functional analysis in induced neurons.

The paper functionally annotates schizophrenia-associated non-coding variants by identifying cell type and condition specific molecular functions and target genes.

The paper shows that neuronal cholesterol synthesis is critical for remyelination in chronic demyelination models and MS patients.