Michael J. McCarthy

This study identifies BHLHE41 as a key regulator of lithium response in bipolar disorder by showing its role in neuronal excitability and synaptic plasticity through genetic and cellular analyses.

This study shows that bipolar disorder patient-derived neurons exhibit circadian rhythm abnormalities, with lithium non-responders showing more severe deficits that can be partially reversed by temperature entrainment.

The paper shows that polygenic scores for depression traits predict lithium response in bipolar disorder patients, with lower genetic load linked to better treatment outcomes.

This study finds that a higher genetic risk for schizophrenia is linked to poorer lithium response in bipolar disorder patients, suggesting potential for personalized treatment strategies.