Epithelial density controls cell migration through an adhesion-nucleus mechanotransduction pathway
Louis Laurent, Thomas Germier, Nicolas Audugé, Helena Canever, Joséphine Schelle, Hugo Lachuer, Philippe P. Girard, Jean‐Baptiste Manneville, François Sipieter, Nicolas Borghi
This study identifies a mechanochemical pathway linking cell density to epithelial migration via ERK, cPLA2, and mechanically regulated signaling from adhesions to the nucleus.
bioRxiv · Apr 24, 2026 · PreprintCell Biology