Mixed cytomegalovirus genotypes in HIV positive mothers show compartmentalization and distinct patterns of transmission to infants.
Juanita Pang, Jennifer A. Slyker, Sunando Roy, Josephine M. Bryant, Claire E. Atkinson, Juliana Cudini, Carey Farquhar, P. D. Griffiths, James Njogu Kiarie, Sofia Morfopoulou, Alison C. Roxby, Helena Tutil, Rachel J. Williams, Soren M. Gantt, Richard A. Goldstein, Judith Breuer
The paper shows that HIV-positive mothers have compartmentalized CMV genotypes, with three infants transmitting a single closely related maternal cervix strain, and identifies gene similarities linked to tissue-tropism and immunomodulation.
eLife · Dec 31, 2020Peer-reviewedGenetic & Genomic Medicine