Josephine M. Bryant

Multi-scale modeling of human tissues from spatial transcriptomics with TERRA

TERRA is a foundation model for spatial transcriptomics that predicts tissue behavior under perturbation and identifies multi-scale biological insights across tissues.

Spatial lung niches shape Pseudomonas aeruginosa persistence

This study uses spatial transcriptomics to map Pseudomonas aeruginosa niches in lung tissue from CF and COPD patients, revealing distinct bacterial states and host interactions linked to infection persistence.

Antibiotic lethality dictates mycobacterial infection outcomes

This study introduces ASCT to assess bacterial killing in real-time and links drug tolerance to clinical outcomes in mycobacterial infections.

High frequency body site translocation of nosocomial Pseudomonas aeruginosa

This study investigates the translocation of Pseudomonas aeruginosa between body sites in hospitalized patients, finding that clones often move from the respiratory tract to the gut.

Mixed cytomegalovirus genotypes in HIV positive mothers show compartmentalization and distinct patterns of transmission to infants.

The paper shows that HIV-positive mothers have compartmentalized CMV genotypes, with three infants transmitting a single closely related maternal cervix strain, and identifies gene similarities linked to tissue-tropism and immunomodulation.