A Systematic Assessment of Robustness in CNS Safety Pharmacology
Maria Reiber, Helen Stirling, Tim P. Ahuis, Washington Arias, Katharina Aulehner, Ute Dreßler, Martien J. Kas, Johanna Kela, Kimberly Kerker, Tarja Kuosmanen, Helga Lorenz, Alexander T. Pennington, Eva‐Lotta von Rüden, Heike Schauerte, Isabel Seiffert, , Heidrun Potschka
This study assesses the robustness of Irwin tests across multiple sites for detecting drug-induced neurological effects in mice, finding reduced variability after protocol harmonization.
British Journal of Pharmacology · Oct 10, 2024Peer-reviewedNeuroscience