Nucleosome binding relinquishes the association of the BAH domain of Orc1 with Sir1
Heli Jiang, Cong Yu, Chao-Pei Liu, Xiaonan Han, Jingjing Chen, Zhenyu Yu, Rui-Ming Xu
The paper shows that the BAH domain of Orc1 loses its ability to bind Sir1 when nucleosomes are present, suggesting a role for chromatin sensing in transcriptional silencing and replication origin specification.
bioRxiv · Mar 14, 2025 · PreprintMolecular Biology