Molecular BiologybioRxivPreprint
Nucleosome binding relinquishes the association of the BAH domain of Orc1 with Sir1
Heli Jiang, Cong Yu, Chao-Pei Liu…·Rui-Ming Xu
The paper shows that the BAH domain of Orc1 loses its ability to bind Sir1 when nucleosomes are present, suggesting a role for chromatin sensing in transcriptional silencing and replication origin specification.
DOI 10.1101/2025.03.14.643217