GFRAL neurons remodel intestinal structure and type 2 immunity
Danielle van de Lisdonk, Onur Eskiocak, Zachary Kerner, Wuqiang Guan, Semir Beyaz, Helmut Kessels, Bo Li
This study shows that GFRAL neurons in the brainstem regulate intestinal structure and type 2 immunity through a vagal circuit, affecting food allergy, helminth infection, and colitis.
bioRxiv · Nov 3, 2026 · PreprintNeuroscience