Bo Li

This study shows that GFRAL neurons in the brainstem regulate intestinal structure and type 2 immunity through a vagal circuit, affecting food allergy, helminth infection, and colitis.

The paper investigates the impact of a methyl group substitution in IL-17 inhibitors, finding that replacing a difluoro group with a methyl significantly improves safety and efficacy.

This paper identifies and characterizes D2469079A, a novel TLR7/8 antagonist with brain penetration, showing efficacy and safety in preclinical models.

This study shows dynorphin modulates motivation via a pallido-amygdala cholinergic circuit by both disinhibiting and autoinhibiting cholinergic transmission in mice.

The paper shows striatal D1 and D2 MSNs regulate BLA ACh levels, influencing salience assignment through distinct mechanisms.

This study identifies area postrema neurons as mediators of IL-6 function in cancer-associated cachexia, showing that targeting these neurons can prevent cachexia and prolong lifespan in mice.

This study shows that low frequency stimulation enhances specific tau phosphorylation sites in aged rats, with potential implications for Alzheimer's disease.

This study shows that specific prefrontal cortex projections to striatum and thalamus differentially control context-dependent strategy switching in mice.

The paper introduces a genetically encoded fluorescent sensor, GRABeCB2.0, to measure endocannabinoid dynamics with high spatiotemporal resolution in vitro and in vivo, revealing new insights into eCB signaling in neurons and brain regions.

This study identifies Neurotensin-expressing neurons in the mouse IPAC that regulate energy balance by modulating feeding behavior and physical activity.

This study identifies sex-specific anxiety-related behavioral and neural circuit changes in a mouse model of 16p11.2 microdeletion.

This study identifies a CeA-GPe circuit that conveys unconditioned stimulus information and controls fear learning in mice.

This study shows that GABAergic and glutamatergic ventral pallidal neurons control opposing motivational behaviors in mice by encoding positive and negative motivational value.

This study shows how associative learning alters BLA population responses, transforming CS representations to resemble US valence-specific representations and enabling flexible behavior during reversal learning.

The paper identifies the insula-central amygdala circuit's role in avoidance behavior by showing its necessity and sufficiency for learning anticipatory avoidance of unpleasant tastants.

The paper identifies a specific class of central amygdala neurons that are essential for synaptic plasticity in the lateral amygdala during learning.